|本期目录/Table of Contents|

[1]李 隽,刘程曦,曹 嵩.蓝斑核-脊髓背角去甲肾上腺素能通路与神经病理性疼痛研究进展[J].遵义医科大学学报,2019,42(05):602-606.
 Li Juan,Liu Chengxi,Cao Song.Research progress of the role of locus coeruleus-spinal dorsal horn noradrenergic pathway in neuropathic pain[J].Journal of Zunyi Medical University,2019,42(05):602-606.
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蓝斑核-脊髓背角去甲肾上腺素能通路与神经病理性疼痛研究进展()
     
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《遵义医科大学学报》[ISSN:1000-9035/CN:22-1262/O4]

卷:
第42卷
期数:
2019年05期
页码:
602-606
栏目:
综述
出版日期:
2019-10-25

文章信息/Info

Title:
Research progress of the role of locus coeruleus-spinal dorsal horn noradrenergic pathway in neuropathic pain
文章编号:
1000-2715(2019)05-0602-05
作者:
李 隽1刘程曦2曹 嵩32
(1.遵义医科大学 研究生院,贵州 遵义 563099; 2.遵义医科大学 贵州省麻醉与器官保护基础研究重点实验室,贵州 遵义 563099; 3.遵义医科大学附属医院 疼痛科,贵州 遵义 563099)
Author(s):
Li Juan1Liu Chengxi2Cao Song23
(1.Graduate School of Zunyi Medical University,Zunyi Guizhou 563099,China; 2.Guizhou Key Laboratory of Anesthesia and Organ Protection,Zunyi Medical University,Zunyi Guizhou 563099,China; 3.Department of Pain Medicine,Affiliated Hospital of Zunyi Medical University,Zunyi Guizhou 563099,China)
关键词:
蓝斑核 去甲肾上腺素 神经病理性疼痛 星形胶质细胞 小胶质细胞 脊髓背角
Keywords:
locus coeruleus norepinephrine neuropathic pain astrocyte microglia spinal dorsal horn
分类号:
R453
DOI:
-
文献标志码:
A
摘要:
神经病理性疼痛发病机制复杂,目前仍缺乏有效的治疗手段。蓝斑核-脊髓背角去甲肾上腺素(Norepinephrine,NE)能通路能缓解神经病理性疼痛,但蓝斑核释放的NE在脊髓背角的细胞和分子机制尚不清楚。本文对该通路在神经病理性疼痛中的作用及可能的机制进行了综述,展望以该通路及NE受体为靶点的镇痛策略的应用前景,为神经病理性疼痛治疗提供了新的研究思路。
Abstract:
The pathogenesis of neuropathic pain is complex,and there is still a lack of effective treatment.Locus coeruleus-spinal dorsal horn noradrenergic pathway can alleviate neuropathic pain,but the cellular and molecular mechanisms of norepinephrine(NE)released into spinal dorsal horn remain unclear.The role of this noradrenergic pathway in neuropathic pain and its possible mechanisms were reviewed.The prospects for the application of analgesia strategies targeting this pathway and NE receptors were proposed,which may provide new research ideas for the treatment of neuropathic pain.

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备注/Memo

备注/Memo:
[基金项目]国家自然科学基金资助项目(NO:81660201; 81960263); 贵州省科技厅省校三方联合基金资助项目(NO:黔科合LH字[2015]7554)。 [通信作者]曹嵩,男,博士,副主任医师,硕士生导师,研究方向:慢性疼痛发病机制及其诊疗,E-mail:caosong4321@163.com。
更新日期/Last Update: 2019-10-25